TIMP2 (Human) ELISA Kit
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Specification
Product Description
TIMP2 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human TIMP2.
Suitable Sample
Cell Culture Supernatant, Plasma (EDTA, Heparin), Serum, Saliva
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
156 to 10000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — TIMP2
Entrez GeneID
7077Gene Name
TIMP2
Gene Alias
CSC-21K
Gene Description
TIMP metallopeptidase inhibitor 2
Omim ID
188825Gene Ontology
HyperlinkGene Summary
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq
Other Designations
tissue inhibitor of metalloproteinase 2|tissue inhibitor of metalloproteinases 2
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Interactome
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Disease
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Publication Reference
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Animal Models of Steatosis (NAFLD) and Steatohepatitis (NASH) Exhibit Hepatic Lobe-Specific Gelatinases Activity and Oxidative Stress.
Palladini G, Di Pasqua LG, Berardo C, Siciliano V, Richelmi P, Perlini S, Ferrigno A, Vairetti M.
Canadian Journal of Gastroenterology & Hepatology 2019 Feb; 2019:5413461.
Application:Quant, Rat, Rat livers.
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TIMP-2 mediated inhibition of angiogenesis: an MMP-independent mechanism.
Seo DW, Li H, Guedez L, Wingfield PT, Diaz T, Salloum R, Wei BY, Stetler-Stevenson WG.
Cell 2003 Jul; 114(2):171.
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Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene.
Hammani K, Blakis A, Morsette D, Bowcock AM, Schmutte C, Henriet P, DeClerck YA.
The Journal of Biological Chemistry 1996 Oct; 271(41):25498.
Application:Quant, Human, EJ, RT4 cells.
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The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25.
De Clerck Y, Szpirer C, Aly MS, Cassiman JJ, Eeckhout Y, Rousseau G.
Genomics 1992 Nov; 14(3):782.
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Animal Models of Steatosis (NAFLD) and Steatohepatitis (NASH) Exhibit Hepatic Lobe-Specific Gelatinases Activity and Oxidative Stress.
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