PLAUR (Human) ELISA Kit
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Specification
Product Description
PLAUR (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human PLAUR.
Suitable Sample
Body Fluid, Cell Culture Supernatant, Plasma, Serum, Tissue Lysate
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
62.5 to 4000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — PLAUR
Entrez GeneID
5329Gene Name
PLAUR
Gene Alias
CD87, UPAR, URKR
Gene Description
plasminogen activator, urokinase receptor
Omim ID
173391Gene Ontology
HyperlinkGene Summary
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq
Other Designations
monocyte activation antigen Mo3|u-plasminogen activator receptor form 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Urokinase plasminogen activator receptor: Prognostic biomarker for endometrial cancer.
Memarzadeh S, Kozak KR, Chang L, Natarajan S, Shintaku P, Reddy ST, Farias-Eisner R.
PNAS 2002 Aug; 99(16):10647.
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cDNA for Mo3, a monocyte activation antigen, encodes the human receptor for urokinase plasminogen activator.
Min HY, Semnani R, Mizukami IF, Watt K, Todd RF 3rd, Liu DY.
Journal of Immunology 1992 Jun; 148(11):3636.
Application:Quant, Monkey, COS cells.
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Assignment of the urokinase-type plasminogen activator receptor gene (PLAUR) to chromosome 19q13.1-q13.2.
Borglum AD, Byskov A, Ragno P, Roldan AL, Tripputi P, Cassani G, Dano K, Blasi F, Bolund L, Kruse TA.
American Journal of Human Genetics 1992 Mar; 50(3):492.
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Urokinase plasminogen activator receptor: Prognostic biomarker for endometrial cancer.
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