CCL11 (Human) ELISA Kit
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Specification
Product Description
CCL11 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human CCL11.
Suitable Sample
Cell Culture Supernatant, Plasma (Citrate, EDTA), Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
15.6 to 1000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — CCL11
Entrez GeneID
6356Gene Name
CCL11
Gene Alias
MGC22554, SCYA11
Gene Description
chemokine (C-C motif) ligand 11
Gene Ontology
HyperlinkGene Summary
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq
Other Designations
eosinophil chemotactic protein|eotaxin|small inducible cytokine A11|small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
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Interactome
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Pathway
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Disease
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Publication Reference
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Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.
Kitaura M, Nakajima T, Imai T, Harada S, Combadiere C, Tiffany HL, Murphy PM, Yoshie O.
The Journal of Biological Chemistry 1996 Mar; 271(13):7725.
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Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5.
Ogilvie P, Bardi G, Clark-Lewis I, Baggiolini M, Uguccioni M.
Blood 2001 Apr; 97(7):1920.
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Genomic organization, sequence, and transcriptional regulation of the human eotaxin gene.
Hein H, Schluter C, Kulke R, Christophers E, Schroder JM, Bartels J.
Biochemical and Biophysical Research Communications 1997 Aug; 237(3):537.
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Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3.
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