CDC2L2 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human CDC2L2 partial ORF ( NP_277073, 681 a.a. - 780 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
GFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.63
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CDC2L2
Entrez GeneID
728642GeneBank Accession#
NM_033531Protein Accession#
NP_277073Gene Name
CDC2L2
Gene Alias
CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, MGC131975, PITSLRE, p58GTA
Gene Description
cell division cycle 2-like 2 (PITSLRE proteins)
Omim ID
116951Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq
Other Designations
PITSLRE B|PITSLRE protein kinase beta|PITSLRE serine/threonine-protein kinase CDC2L2|cell division cycle 2-like 2|cell division cycle 2-like protein kinase 2|galactosyltransferase-associated protein kinase p58/GTA
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Interactome
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