NPHP4 monoclonal antibody (M01A), clone 4D4
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant NPHP4.
Immunogen
NPHP4 (NP_055917.1, 1317 a.a. ~ 1426 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
ASWLVCLCCRQPLISKAFEIMLAAGEGKGVNKRITYTNPYPSRRTFHLHSDHPELLRFREDSFQVGGGETYTIGLQFAPSQRVGEEEILIYINDHEDKNEEAFCVKVIYQ
Host
Mouse
Reactivity
Human
Isotype
IgM Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In ascites fluid
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
ELISA
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Gene Info — NPHP4
Entrez GeneID
261734GeneBank Accession#
NM_015102Protein Accession#
NP_055917.1Gene Name
NPHP4
Gene Alias
KIAA0673, SLSN4
Gene Description
nephronophthisis 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein which contains a proline-rich region. The encoded protein may function in renal tubular development and function. This protein interacts with nephrocystin. Mutations in this gene are associated with nephronophthisis type 4. Multiple alternative transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq
Other Designations
nephrocystin 4|nephroretinin
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Interactome
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Disease
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Publication Reference
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Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.
Jun Wang, Holly R Thomas, Robert G Thompson, Stephanie C Waldrep, Joseph Fogerty, Ping Song, Zhang Li, Yongjie Ma, Peu Santra, Jonathan D Hoover, Nan Cher Yeo, Iain A Drummond, Bradley K Yoder, Jeffrey D Amack, Brian Perkins, John M Parant.
Disease Models & Mechanisms 2022 Dec; 15(12):dmm049568.
Application：WB-Ce, Human, Zebrafish, HEK 293 cells, Zebrafish embryo.
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Interaction of ciliary disease protein retinitis pigmentosa GTPase regulator with nephronophthisis-associated proteins in mammalian retinas.
Murga-Zamalloa CA, Desai NJ, Hildebrandt F, Khanna H.
Molecular Vision 2010 Jul; 16:1373.
Application：WB-Ti, Bovine, Bovine retinal lysates.
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Variable phenotypes and penetrance between and within different zebrafish ciliary transition zone mutants.
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