UNC13D 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-UNC13D full-length
Host
Human
Theoretical MW (kDa)
123.3
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-UNC13D antibody (H00201294-D01P) by Western Blots.
SDS-PAGE Gel
UNC13D transfected lysate.
Western Blot
Lane 1: UNC13D transfected lysate ( 123.30 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — UNC13D
Entrez GeneID
201294GeneBank Accession#
NM_199242.1Protein Accession#
NP_954712.1Gene Name
UNC13D
Gene Alias
FHL3, HLH3, HPLH3, Munc13-4
Gene Description
unc-13 homolog D (C. elegans)
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq
Other Designations
unc-13 homolog D
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Interactome
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Disease
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