GPBAR1 DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human GPBAR1 DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — GPBAR1
Entrez GeneID
151306GeneBank Accession#
BC033625Protein Accession#
AAH33625Gene Name
GPBAR1
Gene Alias
BG37, GPCR, GPCR19, GPR131, M-BAR, MGC40597, TGR5
Gene Description
G protein-coupled bile acid receptor 1
Omim ID
610147Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
G-protein coupled bile acid receptor BG37|membrane bile acid receptor|membrane-type receptor for bile acids
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Disease
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