SIGLEC12 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-SIGLEC12 full-length
Host
Human
Theoretical MW (kDa)
65.56
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-SIGLEC12 antibody (H00089858-B01) by Western Blots.
SDS-PAGE Gel
SIGLEC12 transfected lysate.
Western Blot
Lane 1: SIGLEC12 transfected lysate ( 65.56 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — SIGLEC12
Entrez GeneID
89858GeneBank Accession#
NM_053003.2Protein Accession#
NP_443729.1Gene Name
SIGLEC12
Gene Alias
FLJ38600, S2V, SIGLECL1, SLG, Siglec-12, Siglec-L1, Siglec-XII
Gene Description
sialic acid binding Ig-like lectin 12
Omim ID
606094Gene Ontology
HyperlinkGene Summary
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq
Other Designations
SIGLEC-like 1|sialic acid binding immunoglobulin-like lectin-like protein 1
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Interactome
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Disease
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