PDZD3 DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human PDZD3 DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — PDZD3
Entrez GeneID
79849GeneBank Accession#
NM_024791.2Protein Accession#
NP_079067.2Gene Name
PDZD3
Gene Alias
FLJ22756, IKEPP, PDZK2
Gene Description
PDZ domain containing 3
Omim ID
607146Gene Ontology
HyperlinkGene Summary
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM
Other Designations
PDZ domain containing 2|intestinal and kidney enriched PDZ protein|natrium-phosphate cotransporter IIa C-terminal-associated protein 2
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