DNASE2B (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human DNASE2B full-length ORF ( NP_490649.1, 1 a.a. - 153 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MPQLCTRASSSEIPGRLLTTLQSAQGQKFLHFAKSDSFLDDIFAAWMAQRLKTHLLTETWQRKRQELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESCK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
44.2
Interspecies Antigen Sequence
Mouse (66); Rat (67)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — DNASE2B
Entrez GeneID
58511GeneBank Accession#
NM_058248.1Protein Accession#
NP_490649.1Gene Name
DNASE2B
Gene Alias
DLAD
Gene Description
deoxyribonuclease II beta
Omim ID
608057Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq
Other Designations
DNase II-like acid DNase|OTTHUMP00000011481|endonuclease DLAD|lysosomal DNase II
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Interactome
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Pathway
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