NEIL3 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human NEIL3 peptide using ARM Technology.
Immunogen
A synthetic peptide of human NEIL3 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human NEIL3 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — NEIL3
Entrez GeneID
55247GeneBank Accession#
NEIL3Gene Name
NEIL3
Gene Alias
FGP2, FLJ10858, FPG2, NEI3, hFPG2, hNEI3
Gene Description
nei endonuclease VIII-like 3 (E. coli)
Omim ID
608934Gene Ontology
HyperlinkGene Summary
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM
Other Designations
DNA glycosylase hFPG2|nei endonuclease VIII-like 3
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