FBXW5 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human FBXW5 full-length ORF ( AAH00850.1, 1 a.a. - 159 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MGLSPDNRYLYVNSRAWPNGAVVADPMQPPPIAEEIDLLVFDLKTMREVRRALRAHRAYTPNDECFFIFLDVSRDFVASGAEDRHGYIWDRHYNICLARLRHEDVVNSVVFSPQEQELLLTASDDATIKAWRSPRTMRVLQAPRPRPRTFFSWLASQRR
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
44.9
Interspecies Antigen Sequence
Mouse (91); Rat (93)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — FBXW5
Entrez GeneID
54461GeneBank Accession#
BC000850.1Protein Accession#
AAH00850.1Gene Name
FBXW5
Gene Alias
DKFZp434B205, Fbw5, MGC20962, RP11-229P13.10
Gene Description
F-box and WD repeat domain containing 5
Omim ID
609072Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq
Other Designations
F-box and WD-40 domain protein 5|OTTHUMP00000022659|WD repeat-containing F-box protein FBW5
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Interactome
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