APH1A DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human APH1A DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MGAAVFFGCTFVAFGPAFALFLITVAGDPLRVIILVAGAFFWLVSLLLASVVWFILVHVTDRSDARLQYGLLIFGAAVSVLLQEVFRFAYYKLLKKADEGLASLSEDGRSPISIRQMAYVSGLSFGIISGVFSVINILADALGPGVVGIHGDSPYYFLTSAFLTAAIILLHTFWGVVFFDACERRRYWALGLVVGSHLLTSGLTFLNPWYEASLLPIYAVTVSMGLWAFITAGGSLRSIQRSLLCKD
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — APH1A
Entrez GeneID
51107GeneBank Accession#
NM_016022.2Protein Accession#
NP_057106.2Gene Name
APH1A
Gene Alias
6530402N02Rik, APH-1A, CGI-78
Gene Description
anterior pharynx defective 1 homolog A (C. elegans)
Omim ID
607629Gene Ontology
HyperlinkGene Summary
APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM
Other Designations
OTTHUMP00000014528|OTTHUMP00000014529|anterior pharynx defective 1 homolog A
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Interactome
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Pathway
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Disease
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