ARHGEF3 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
ARHGEF3 transfected lysate.
Western Blot
Lane 1: ARHGEF3 transfected lysate ( 37 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ARHGEF3 full-length
Host
Human
Theoretical MW (kDa)
35.75
Interspecies Antigen Sequence
Mouse (94); Rat (94)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ARHGEF3 antibody (H00050650-B01) by Western Blots.
SDS-PAGE Gel
ARHGEF3 transfected lysate.
Western Blot
Lane 1: ARHGEF3 transfected lysate ( 37 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ARHGEF3
Entrez GeneID
50650GeneBank Accession#
BC099715Protein Accession#
AAH99715Gene Name
ARHGEF3
Gene Alias
DKFZp434F2429, FLJ98126, GEF3, MGC118905, STA3, XPLN
Gene Description
Rho guanine nucleotide exchange factor (GEF) 3
Gene Ontology
HyperlinkGene Summary
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
59.8 kDA protein|Rho guanine nucleotide exchange factor 3|RhoGEF protein|exchange factor found in platelets and leukemic and neuronal tissues, XPLN
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Interactome
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