ARHGEF3 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human ARHGEF3 peptide using ARM Technology.
Immunogen
A synthetic peptide of human ARHGEF3 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human ARHGEF3 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — ARHGEF3
Entrez GeneID
50650GeneBank Accession#
ARHGEF3Gene Name
ARHGEF3
Gene Alias
DKFZp434F2429, FLJ98126, GEF3, MGC118905, STA3, XPLN
Gene Description
Rho guanine nucleotide exchange factor (GEF) 3
Gene Ontology
HyperlinkGene Summary
Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
59.8 kDA protein|Rho guanine nucleotide exchange factor 3|RhoGEF protein|exchange factor found in platelets and leukemic and neuronal tissues, XPLN
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Interactome
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Disease
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