IBTK rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human IBTK peptide using ARM Technology.
Immunogen
A synthetic peptide of human IBTK is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human IBTK peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — IBTK
Entrez GeneID
25998GeneBank Accession#
IBTKGene Name
IBTK
Gene Alias
BTKI, KIAA1417, MGC142256, MGC142258, RP1-93K22.1
Gene Description
inhibitor of Bruton agammaglobulinemia tyrosine kinase
Omim ID
606457Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. [provided by RefSeq
Other Designations
BTK-binding protein|Bruton agammaglobulinemia tyrosine kinase inhibitor|OTTHUMP00000040002|inhibitor of Bruton's tyrosine kinase|inhibitor of Bruton's tyrosine kinase-alpha|inhibitor of Bruton's tyrosine kinase-beta|inhibitor of Bruton's tyrosine kinase-g
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Interactome
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Toll Free : +1-877-853-6098 - +1-909-992-3401
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