Products

Western Blot (Transfected lysate)

Immunofluorescence (Transfected cell)

Flow Cytometry (Transfected cell)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

RNF19A

Gene Alias

DKFZp566B1346, DORFIN, RNF19

Gene Description

ring finger protein 19A

Omim ID

Gene Ontology

Gene Summary

The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq

Other Designations

RING finger protein 19 isoform|double ring-finger protein|p38 protein|protein p38 interacting with transcription factor Sp1|ring finger protein 19|ring-IBR-ring domain containing protein Dorfin