GCA DNAxPab
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human GCA DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MAYPGYGGGFGNFSIQVPGMQMGQPVPETGPAILLDGYSGPAYSDTYSSAGDSVYTYFSAVAGQDGEVDAEELQRCLTQSGINGTYSPFSLETCRIMIAMLDRDHTGKMGFNAFKELWAALNAWKENFMTVDQDGSGTVEHHELRQAIGLMGYRLSPQTLTTIVKRYSKNGRIFFDDYVACCVKLRALTDFFRKRDHLQQGSANFIYDDFLQGTMAI
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — GCA
Entrez GeneID
25801GeneBank Accession#
NM_012198.2Protein Accession#
NP_036330.1Gene Name
GCA
Gene Alias
GCL
Gene Description
grancalcin, EF-hand calcium binding protein
Omim ID
607030Gene Ontology
HyperlinkGene Summary
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation. [provided by RefSeq
Other Designations
grancalcin, EF-hand calcium-binding protein|grancalcin, penta-EF-hand protein
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Interactome
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Disease
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