ZNF278 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ZNF278 full-length
Host
Human
Theoretical MW (kDa)
59.18
Interspecies Antigen Sequence
Mouse (98); Rat (99)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ZNF278 antibody (H00023598-B01) by Western Blots.
SDS-PAGE Gel
PATZ1 transfected lysate.
Western Blot
Lane 1: PATZ1 transfected lysate ( 59.18 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PATZ1
Entrez GeneID
23598GeneBank Accession#
NM_032051.1Protein Accession#
NP_114440.1Gene Name
PATZ1
Gene Alias
MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23
Gene Description
POZ (BTB) and AT hook containing zinc finger 1
Omim ID
605165Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq
Other Designations
BTB-POZ domain zinc finger transcription factor|MAZ-related factor|POZ-AT hook-zinc finger protein|zinc finger protein 278
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Interactome
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Disease
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