DUSP12 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
DUSP12 transfected lysate.
Western Blot
Lane 1: DUSP12 transfected lysate ( 37.51 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-DUSP12 full-length
Host
Human
Theoretical MW (kDa)
37.51
Interspecies Antigen Sequence
Mouse (83); Rat (82)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-DUSP12 antibody (H00011266-B01) by Western Blots.
SDS-PAGE Gel
DUSP12 transfected lysate.
Western Blot
Lane 1: DUSP12 transfected lysate ( 37.51 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — DUSP12
Entrez GeneID
11266GeneBank Accession#
NM_007240.1Protein Accession#
NP_009171.1Gene Name
DUSP12
Gene Alias
DUSP1, YVH1
Gene Description
dual specificity phosphatase 12
Omim ID
604835Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain. [provided by RefSeq
Other Designations
OTTHUMP00000032494|YVH1 protein-tyrosine phosphatase ortholog|serine/threonine specific protein phosphatase
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