DUSP14 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human DUSP14 full-length ORF ( AAH00370, 1 a.a. - 198 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTPYGIVPDVYEKESRHLMPYWGI
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
47.52
Interspecies Antigen Sequence
Mouse (93); Rat (94)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Phosphatase Assay (Cdc25)
Phosphatase Assay (PTP)
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — DUSP14
Entrez GeneID
11072GeneBank Accession#
BC000370Protein Accession#
AAH00370Gene Name
DUSP14
Gene Alias
MKP-L, MKP6
Gene Description
dual specificity phosphatase 14
Omim ID
606618Gene Ontology
HyperlinkGene Summary
In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.[supplied by OMIM
Other Designations
MKP-1 like protein tyrosine phosphatase|OTTHUMP00000164064|OTTHUMP00000164065
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Interactome
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Pathway
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