PRPF8 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human PRPF8 full-length ORF ( AAH00579.1, 1 a.a. - 267 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAGVFPYRGPGNPVPGPLAPLPDYMSEEKLQEKARKWQQLQAKRYAEKRKFGFVDAQKEDMPPEHVRKIIRDHGDMTNRKFRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVPVLYHITGAISFVNEIPWVIEPVYISQWGSMWIMMRREKRDRRHFKRMRFPPFDDEEPPLDYADNILDVEPLEAIQLELDPEEDAPVLDWFYDHQPLRDSRKYVNGSTYQRWQFTLPMMSPPMPRSWLTTHLGMARRPLSSHAASRQAPVH
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
58.1
Interspecies Antigen Sequence
Mouse (100); Rat (100)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PRPF8
Entrez GeneID
10594GeneBank Accession#
BC000579.2Protein Accession#
AAH00579.1Gene Name
PRPF8
Gene Alias
HPRP8, PRP8, PRPC8, RP13
Gene Description
PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)
Gene Ontology
HyperlinkGene Summary
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq
Other Designations
U5 snRNP-specific protein|U5 snRNP-specific protein (220 kD), ortholog of S. cerevisiae Prp8p|apoptosis-regulated protein 1|apoptosis-regulated protein 2|precursor mRNA processing protein|splicing factor Prp8
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Interactome
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Disease
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