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Western Blot

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

MAP3K7IP1

Gene Alias

3'-Tab1, MGC57664, TAB1

Gene Description

mitogen-activated protein kinase kinase kinase 7 interacting protein 1

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq

Other Designations

TAK1-binding protein 1|transforming growth factor beta-activated kinase-binding protein 1