PSME3 293T Cell Transient Overexpression Lysate(Denatured)
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Specifications
Transfected Cell Line
293T
Plasmid
pCMV-PSME3 full-length
Host
Human
Theoretical MW (kDa)
28.05
Interspecies Antigen Sequence
Mouse (100); Rat (100)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PSME3 antibody (H00010197-B01) by Western Blots.
SDS-PAGE Gel
PSME3 transfected lysate
Western Blot
Lane 1: PSME3 transfected lysate ( 28.05 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — PSME3
Entrez GeneID
10197GeneBank Accession#
BC001423Protein Accession#
AAH01423Gene Name
PSME3
Gene Alias
Ki, PA28-gamma, PA28G, REG-GAMMA
Gene Description
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
Omim ID
605129Gene Ontology
HyperlinkGene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
11S regulator complex gamma subunit|Ki antigen|Ki nuclear autoantigen|activator of multicatalytic protease subunit 3|proteasome activator 28-gamma|proteasome activator subunit 3
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Interactomes
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