NOS1AP rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human NOS1AP peptide using ARM Technology.
Immunogen
A synthetic peptide of human NOS1AP is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human NOS1AP peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — NOS1AP
Entrez GeneID
9722GeneBank Accession#
NOS1APGene Name
NOS1AP
Gene Alias
6330408P19Rik, CAPON, MGC138500
Gene Description
nitric oxide synthase 1 (neuronal) adaptor protein
Gene Ontology
HyperlinkGene Summary
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)|OTTHUMP00000025714|ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain
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Interactome
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Disease
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