MBTPS1 rabbit monoclonal antibody
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Specification
Product Description
Rabbit monoclonal antibody raised against a human MBTPS1 peptide using ARM Technology.
Immunogen
A synthetic peptide of human MBTPS1 is used for rabbit immunization.
Customer or Abnova will decide on the preferred peptide sequence.Host
Rabbit
Library Construction
Non-fusion antibody library from rabbit spleen (ARM Technology).
Expression
Overexpression vector and transfection into 293H cell line.
Reactivity
Human
Purification
Protein A
Isotype
IgG
Quality Control Testing
Antibody reactive against human MBTPS1 peptide by ELISA and mammalian transfected lysate by Western Blot.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Deliverable
Up to three rabbit IgG clones of 100 ug each will be delivered to customer.
Note
1. Customer may provide cell or tissue lysate for antibody screening.
2. Rabbit monoclonal antibody generated by ARM technology is amenable to antibody engineering including F(ab)2, IgG, scFv and different Fc and non-Fc conjugates per customer request. -
Applications
Western Blot (Transfected lysate)
ELISA
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Gene Info — MBTPS1
Entrez GeneID
8720GeneBank Accession#
MBTPS1Gene Name
MBTPS1
Gene Alias
KIAA0091, MGC138711, MGC138712, PCSK8, S1P, SKI-1
Gene Description
membrane-bound transcription factor peptidase, site 1
Omim ID
603355Gene Ontology
HyperlinkGene Summary
The encoded protein has a central role in the regulation of lipid metabolism in cells. It is a sterol-regulated subtilisin-like serine protease that cleaves ER membrane-bound sterol regulatory element-binding proteins (SREBPs), a reaction that initiates the two-step proteolytic process by which transcriptionally active fragments of SREBPs are released from the membrane for translocation to the nucleus. The gene product is an integral membrane ER protein, with the bulk located in the ER lumen. It is synthesized as an inactive preproprotein that is self-activated by an intramolecular cleavage that generates the mature protein. [provided by RefSeq
Other Designations
membrane-bound transcription factor protease, site 1|membrane-bound transcription factor site-1 protease|site-1 protease|subtilisin/kexin isozyme-1
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Interactome
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Disease
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