NR0B2 monoclonal antibody (M01), clone 1A11
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More Files
- More Functions
Western Blot (Tissue lysate)
NR0B2 monoclonal antibody (M01), clone 1A11. Western Blot analysis of NR0B2 expression in human colon.
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged NR0B2 is approximately 3ng/ml as a capture antibody.
Immunofluorescence
Immunofluorescence of monoclonal antibody to NR0B2 on HeLa cell . [antibody concentration 10 ug/ml]
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant NR0B2.
Immunogen
NR0B2 (AAH30207, 1 a.a. ~ 257 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSTSQPGACPCQGAASRPAILYALLSSSLKAVPRPRSRCLCRQHRPVQLCAPHRTCREALDVLAKTVAFLRNLPSFWQLPPQDQRRLLQGCWGPLFLLGLAQDAVTFEVAEAPVPSILKKILLEEPSSSGGSGQLPDRPQPSLAAVQWLQCCLESFWSLELSPKEYACLKGTILFNPDVPGLQAASHIGHLQQEAHWVLCEVLEPWCPAAQGRLTRVLLTASTLKSIPTSLLGDLFFRPIIGDVDIAGLLGDMLLLR
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (78); Rat (78)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
NR0B2 monoclonal antibody (M01), clone 1A11. Western Blot analysis of NR0B2 expression in human colon.Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged NR0B2 is approximately 3ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to NR0B2 on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — NR0B2
Entrez GeneID
8431GeneBank Accession#
BC030207Protein Accession#
AAH30207Gene Name
NR0B2
Gene Alias
FLJ17090, SHP, SHP1
Gene Description
nuclear receptor subfamily 0, group B, member 2
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq
Other Designations
OTTHUMP00000004414|orphan nuclear receptor SHP|short heterodimer partner|small heterodimer partner
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Interactome
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Disease
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