AXIN2 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human AXIN2 full-length ORF ( AAH06295.1, 1 a.a. - 160 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVANDFCHDILFYLYCKLCIIKSSFKENYLVQ
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
44.4
Interspecies Antigen Sequence
Mouse (95); Rat (95)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — AXIN2
Entrez GeneID
8313GeneBank Accession#
BC006295.2Protein Accession#
AAH06295.1Gene Name
AXIN2
Gene Alias
AXIL, DKFZp781B0869, MGC10366, MGC126582
Gene Description
axin 2
Gene Ontology
HyperlinkGene Summary
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq
Other Designations
conductin
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Interactome
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Pathway
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Disease
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