ZP3 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human ZP3 protein.
Immunogen
ZP3 (AAI46483.1, 1 a.a. ~ 373 a.a) full-length human protein.
Sequence
MVMVSKDLFGTGKLIRAADLTLGPEACEPLVSMDTEDVVRFEVGLHECGNSMQVTDDALVYSTFLLHDPRPVGNLSIVRTNRAEIPIECRYPRQGNVSSQAILPTWLPFRTTVFSEEKLTFSLRLMEENWNAEKRSPTFHLGDAAHLQAEIHTGSHVPLRLFVDHCVATPTPDQNASPYHTIVDFHGCLVDGLTDASSAFKVPRPGPDTLQFTVDVFHFANDSRNMIYITCHLKVTLAEQDPDELNKACSFSKPSNSWFPVEGSADICQCCNKGDCGTPSHSRRQPHVMSQWSRSASRNRRHVTEEADVTVGPLIFLDRRGDHEVEQWALPSDTSVVLLGVGLAVVVSLTLTAVILVLTRRCRTASHPVSASE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (69); Rat (67)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of ZP3 expression in transfected 293T cell line (H00007784-T01) by ZP3 MaxPab polyclonal antibody.
Lane 1: ZP3 transfected lysate(41.03 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — ZP3
Entrez GeneID
7784GeneBank Accession#
BC146482Protein Accession#
AAI46483.1Gene Name
ZP3
Gene Alias
ZP3A, ZP3B, ZPC
Gene Description
zona pellucida glycoprotein 3 (sperm receptor)
Omim ID
182889Gene Ontology
HyperlinkGene Summary
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq
Other Designations
zona pellucida glycoprotein 3|zona pellucida glycoprotein 3A (sperm receptor)|zona pellucida glycoprotein 3B|zona pellucida protein C|zona pellucida sperm-binding protein 3
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