ZAP70 293T Cell Transient Overexpression Lysate(Denatured)
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More Files
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SDS-PAGE Gel
ZAP70 transfected lysate.
Western Blot
Lane 1: ZAP70 transfected lysate ( 69.90 KDa)
Lane 2: Non-transfected lysate.
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-ZAP70 full-length
Host
Human
Theoretical MW (kDa)
69.9
Interspecies Antigen Sequence
Mouse (94); Rat (93)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-ZAP70 antibody (H00007535-D01P) by Western Blots.
SDS-PAGE Gel
ZAP70 transfected lysate.
Western Blot
Lane 1: ZAP70 transfected lysate ( 69.90 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — ZAP70
Entrez GeneID
7535GeneBank Accession#
NM_001079Protein Accession#
AAH53878.1Gene Name
ZAP70
Gene Alias
FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Gene Description
zeta-chain (TCR) associated protein kinase 70kDa
Omim ID
176947Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq
Other Designations
syk-related tyrosine kinase|zeta-chain (TCR) associated protein kinase (70 kD)|zeta-chain associated protein kinase 70kDa|zeta-chain associated protein kinase, 70kD
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Interactome
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Pathway
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Disease
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