WRN monoclonal antibody (M09), clone 3C11
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant WRN.
Immunogen
WRN (NP_000544, 1322 a.a. ~ 1432 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
NPPVNSDMSKISLIRMLAPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (61)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.95 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
WRN monoclonal antibody (M09), clone 3C11 Western Blot analysis of WRN expression in Hela S3 NE ( Cat # L013V3 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged WRN is approximately 0.3ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to WRN on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — WRN
Entrez GeneID
7486GeneBank Accession#
NM_000553Protein Accession#
NP_000544Gene Name
WRN
Gene Alias
DKFZp686C2056, RECQ3, RECQL2, RECQL3
Gene Description
Werner syndrome
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq
Other Designations
Werner Syndrome helicase|Werner syndrome protein
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Interactome
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Disease
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