Products

Western Blot (Transfected lysate)

Immunofluorescence (Transfected cell)

Flow Cytometry (Transfected cell)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

WHSC1

Gene Alias

FLJ23286, KIAA1090, MGC176638, MMSET, NSD2, REIIBP, TRX5, WHS

Gene Description

Wolf-Hirschhorn syndrome candidate 1

Omim ID

Gene Ontology

Gene Summary

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences. [provided by RefSeq

Other Designations

IL5 promoter REII region-binding protein|OTTHUMP00000149955|OTTHUMP00000159146|Wolf-Hirschhorn syndrome candidate 1 protein|multiple myeloma SET domain containing protein type III|trithorax/ash1-related protein 5