TPMT DNAxPab
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human TPMT DNA using DNAx™ Immune technology.
Technology
Immunogen
Full-length human DNA
Sequence
MDGTRTSLDIEEYSDTEVQKNQVLTLEEWQDKWVNGKTAFHQEQGHQLLKKHLDTFLKGKSGLRVFFPLCGKAVEMKWFADRGHSVVGVEISELGIQEFFTEQNLSYSEEPITEIPGTKVFKSSSGNISLYCCSIFDLPRTNIGKFDMIWDRGALVAINPGDRKCYADTMFSLLGKKFQYLLCVLSYDPTKHPGPPFYVPHAEIERLFGKICNIRCLEKVDAFEERHKSWGIDCLFEKLYLLTEK
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — TPMT
Entrez GeneID
7172GeneBank Accession#
NM_000367.2Protein Accession#
NP_000358.1Gene Name
TPMT
Gene Alias
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Gene Description
thiopurine S-methyltransferase
Gene Ontology
HyperlinkGene Summary
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. [provided by RefSeq
Other Designations
OTTHUMP00000016076|S-adenosyl-L-methionine:thiopurine S-methyltransferase|thiopurine methyltransferase
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Interactome
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Pathway
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Disease
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