TBCC monoclonal antibody (M04), clone 3D3
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More Files
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Specifications
Product Description
Mouse monoclonal antibody raised against a full-length recombinant TBCC.
Immunogen
TBCC (AAH20170.1, 1 a.a. ~ 346 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MESVSCSAAAVRTGDMESQRDLSLVPERLQRREQERQLEVERRKQKRQNQEVEKENSHFFVATFARERAAVEELLERAESVERLEEAASRLQGLQKLINDSVFFLAAYDLRQGQEALARLQAALAERRRGLQPKKRFAFKTRGKDAASSTKVDAAPGIPPAVESIQDSPLPKKAEGDLGPSWVCGFSNLESQVLEKRASELHQRDVLLTELSNCTVRLYGNPNTLRLTKAHSCKLLCGPVSTSVFLEDCSDCVLAVACQQLRIHSTKDTRIFLQVTSRAIVEDCSGIQFAPYTWSYPEIDKDFESSGLDRSKNNWNDVDDFNWLARDMASPNWSILPEEERNIQWD
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (76); Rat (75)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (63.8 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged TBCC is 0.3 ng/ml as a capture antibody.ELISA
Immunofluorescence
Immunofluorescence of monoclonal antibody to TBCC on HeLa cell . [antibody concentration 10 ug/ml] -
Gene Info — TBCC
Entrez GeneID
6903GeneBank Accession#
BC020170Protein Accession#
AAH20170.1Gene Name
TBCC
Gene Alias
CFC
Gene Description
tubulin folding cofactor C
Omim ID
602971Gene Ontology
HyperlinkGene Summary
Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq
Other Designations
OTTHUMP00000016406|beta-tubulin cofactor C|tubulin-specific chaperone c
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Interactomes
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Publication Reference
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The solution structure of the N-terminal domain of human tubulin binding cofactor C reveals a platform for tubulin interaction.
Garcia-Mayoral MF, Castano R, Fanarraga ML, Zabala JC, Rico M, Bruix M.
PLoS One 2011 Oct; 6(10):e25912.
Application:IF, WB-Ce, Human, HEK293T, HeLa cells.
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Silencing of tubulin binding cofactor C modifies microtubule dynamics and cell cycle distribution and enhances sensitivity to gemcitabine in breast cancer cells.
Hage-Sleiman R, Herveau S, Matera EL, Laurier JF, Dumontet C.
Molecular Cancer Therapeutics 2011 Feb; 10(2):303.
Application:IF, Human, MCF7 cells.
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Tubulin binding cofactor C (TBCC) suppresses tumor growth and enhances chemosensitivity in human breast cancer cells.
Hage-Sleiman R, Herveau S, Matera EL, Laurier JF, Dumontet C.
BMC Cancer 2010 Apr; 10:135.
Application:IF, Human, MC+1 and MP6.1 cells.
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The solution structure of the N-terminal domain of human tubulin binding cofactor C reveals a platform for tubulin interaction.
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