SREBF1 monoclonal antibody (M03), clone 4G4
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant SREBF1.
Immunogen
SREBF1 (AAH57388, 801 a.a. ~ 900 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
VTQLFREHLLERALNCVTQPNPSPGSADGDKEFSDALGYLQLLNSCSDAAGAPAYSFSISSSMATTTGVDPVAKWWASLTAVVIHWLRRDEEAAERLCPL
Host
Mouse
Reactivity
Human
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
SREBF1 monoclonal antibody (M03), clone 4G4 Western Blot analysis of SREBF1 expression in HeLa ( Cat # L013V1 ).Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged SREBF1 is approximately 0.03ng/ml as a capture antibody.ELISA
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Gene Info — SREBF1
Entrez GeneID
6720GeneBank Accession#
BC057388Protein Accession#
AAH57388Gene Name
SREBF1
Gene Alias
SREBP-1c, SREBP1, bHLHd1
Gene Description
sterol regulatory element binding transcription factor 1
Omim ID
184756Gene Ontology
HyperlinkGene Summary
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
sterol regulatory element binding protein-1
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Interactome
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Pathway
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Disease
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