RORB (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human RORB full-length ORF ( NP_008845.2, 1 a.a. - 459 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MRAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
78.5
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — RORB
Entrez GeneID
6096GeneBank Accession#
NM_006914.3Protein Accession#
NP_008845.2Gene Name
RORB
Gene Alias
NR1F2, ROR-BETA, RZR-BETA, RZRB, bA133M9.1
Gene Description
RAR-related orphan receptor B
Omim ID
601972Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation. [provided by RefSeq
Other Designations
OTTHUMP00000021486|RAR-related orphan receptor beta|nuclear receptor RZR-beta|retinoic acid-binding receptor beta|retinoid-related orphan receptor beta
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Interactome
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Disease
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Publication Reference
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GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers.
Clark EA, Wu F, Chen Y, Kang P, Kaiser UB, Fang R, Shi YG.
Cell Reports 2019 Jun; 27(12):3522.
Application:Func, Recombinant protein.
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GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers.
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