Products

Enzyme-linked Immunoabsorbent Assay

Western Blot (Recombinant protein)

Antibody Production

Protein Array

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

PTPN13

Gene Alias

DKFZp686J1497, FAP-1, PNP1, PTP-BAS, PTP-BL, PTP1E, PTPL1, PTPLE

Gene Description

protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq

Other Designations

APO-1/CD95 (Fas)-associated phosphatase|Fas-associated phosphatase-1|protein tyrosine phosphatase 1E|protein tyrosine phosphatase, non-receptor type 13|protein tyrosine phosphatase, nonreceptor type 13|protein-tyrosine phosphatase 1, Fas-associated|protei