PLP1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human PLP1 partial ORF ( NP_000524, 177 a.a. - 232 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
YFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAE
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
31.9
Interspecies Antigen Sequence
Mouse (100); Rat (100)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PLP1
Entrez GeneID
5354GeneBank Accession#
NM_000533Protein Accession#
NP_000524Gene Name
PLP1
Gene Alias
HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2
Gene Description
proteolipid protein 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000023761|OTTHUMP00000023762|lipophilin|major myelin proteolipid protein
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Interactome
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Disease
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Publication Reference
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Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis.
Quintana FJ, Farez MF, Viglietta V, Iglesias AH, Merbl Y, Izquierdo G, Lucas M, Basso AS, Khoury SJ, Lucchinetti CF, Cohen IR, Weiner HL.
PNAS 2008 Nov; 105(48):18889.
Application:Array, Human, Serum from patients with Multiple sclerosis (MS).
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Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis.
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