PCMT1 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human PCMT1 full-length ORF ( AAH07501.1, 1 a.a. - 228 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAWKSGGASHSELIHNLRKNGIIKTDKVFEVMLATDRSHYAKCNPYMDSPQSIGFQATISAPHMHAYALELLFDQLHEGAKALDVGSGSGILTACFARMVGCTGKVIGIDHIKELVDDSVNNVRKDDPTLLSSGRVQLVVGDGRMGYAEEAPYDAIHVGAAAPVVPQALIDQLKPGGRLILPVGPAGGNQMLEQYDKLQDGSIKMKPLMGVIYVPLTDKEKQWSRDEL
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
50.82
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PCMT1
Entrez GeneID
5110GeneBank Accession#
BC007501Protein Accession#
AAH07501.1Gene Name
PCMT1
Gene Alias
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Gene Description
protein-L-isoaspartate (D-aspartate) O-methyltransferase
Omim ID
176851Gene Ontology
HyperlinkGene Summary
Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM
Other Designations
L-isoaspartyl/D-aspartyl methyltransferase|OTTHUMP00000017398|OTTHUMP00000017400
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Interactome
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Disease
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