OPHN1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human OPHN1 partial ORF ( NP_002538, 641 a.a. - 734 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
QRSGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEGDADSFSKVRPPGEK
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
36.08
Interspecies Antigen Sequence
Mouse (79); Rat (78)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — OPHN1
Entrez GeneID
4983GeneBank Accession#
NM_002547Protein Accession#
NP_002538Gene Name
OPHN1
Gene Alias
MRX60, OPN1
Gene Description
oligophrenin 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism. [provided by RefSeq
Other Designations
OTTHUMP00000023451|mental retardation, X-linked 60|oligophrenin-1, Rho-GTPase activating protein
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Interactome
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Disease
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