NF2 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-NF2 full-length
Host
Human
Theoretical MW (kDa)
55.88
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-NF2 antibody (H00004771-B02) by Western Blots.
Western Blot
Lane 1: NF2 transfected lysate ( 59.1 KDa)
Lane 2: Non-transfected lysate.SDS-PAGE Gel
NF2 transfected lysate.
Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — NF2
Entrez GeneID
4771GeneBank Accession#
NM_181830Protein Accession#
NP_861968Gene Name
NF2
Gene Alias
ACN, BANF, SCH
Gene Description
neurofibromin 2 (merlin)
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq
Other Designations
merlin|moesin-ezrin-radixin like|moesin-ezrin-radizin-like protein|neurofibromin 2|neurofibromin 2 (bilateral acoustic neuroma)|schwannomerlin|schwannomin
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Interactome
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Disease
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