MXI1 monoclonal antibody (M08), clone 1F3
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of MXI1 expression in transfected 293T cell line by MXI1 monoclonal antibody (M08), clone 1F3.
Lane 1: MXI1 transfected lysate(26.1 KDa).
Lane 2: Non-transfected lysate.
Western Blot detection against Immunogen (37.84 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant MXI1.
Immunogen
MXI1 (NP_001008541.1, 73 a.a. ~ 182 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
LEEAERKSQHQLENLEREQRFLKWRLEQLQGPQEMERIRMDSIGSTISSDRSDSEREEIEVDVESTEFSHGEVDNISTTSISDIDDHSSLPSIGSDEGYSSASVKLSFTS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (93); Rat (98)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37.84 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of MXI1 expression in transfected 293T cell line by MXI1 monoclonal antibody (M08), clone 1F3.
Lane 1: MXI1 transfected lysate(26.1 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — MXI1
Entrez GeneID
4601GeneBank Accession#
NM_001008541Protein Accession#
NP_001008541.1Gene Name
MXI1
Gene Alias
MAD2, MGC43220, MXD2, MXI, bHLHc11
Gene Description
MAX interactor 1
Gene Ontology
HyperlinkGene Summary
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq
Other Designations
MAX dimerization protein 2|MAX interacting protein 1|MAX-interacting protein 1|Max-related transcription factor|OTTHUMP00000020467|OTTHUMP00000020468|OTTHUMP00000020469
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Interactome
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Disease
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