MAP3K3 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human MAP3K3 full-length ORF ( AAH10464, 1 a.a. - 90 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MNEANVMLPYSGKEEPVLPVAMTLPLPGRGPRCGTAATEGGSSFVNAVVSVLQVGVTLMLYPVSKLETVCALWALSTPALGLGLGCIEKS
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
35.64
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — MAP3K3
Entrez GeneID
4215GeneBank Accession#
BC010464Protein Accession#
AAH10464Gene Name
MAP3K3
Gene Alias
MAPKKK3, MEKK3
Gene Description
mitogen-activated protein kinase kinase kinase 3
Omim ID
602539Gene Ontology
HyperlinkGene Summary
This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq
Other Designations
MAP/ERK kinase kinase 3|MAPK/ERK kinase kinase 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Regulation of endothelial cell survival and death by the MAP kinase/ERK kinase kinase 3 - glyceraldehyde-3-phosphate dehydrogenase signaling axis.
Li Y, Ngo A, Hoffmann P, Ferrante A, Hii CS.
Cellular Signalling 2019 Mar; 58:20.
Application:Func, Human, HUVECs.
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Regulation of endothelial cell survival and death by the MAP kinase/ERK kinase kinase 3 - glyceraldehyde-3-phosphate dehydrogenase signaling axis.
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