KCNN3 DNAxPab
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Specification
Product Description
Rabbit polyclonal antibody raised against a partial-length human KCNN3 DNA using DNAx™ Immune technology.
Technology
Immunogen
Extracellular membrane domain (ECD) human DNA
Host
Rabbit
Reactivity
Human
Purification
Protein A
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Immunofluorescence (Transfected cell)
Flow Cytometry (Transfected cell)
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Gene Info — KCNN3
Entrez GeneID
3782GeneBank Accession#
NM_170782.1Protein Accession#
NP_740752.1Gene Name
KCNN3
Gene Alias
KCa2.3, SK3, SKCA3, hSK3
Gene Description
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
Omim ID
602983Gene Ontology
HyperlinkGene Summary
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding two different isoforms have been found for this gene. One of the variants lacks the CAG repeat regions. [provided by RefSeq
Other Designations
OTTHUMP00000035369|OTTHUMP00000042458|OTTHUMP00000042459|small conductance calcium-activated potassium channel protein 3
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Interactome
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Disease
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