ITPA (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human ITPA full-length ORF ( AAH10138, 1 a.a. - 194 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAVRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFGSLAA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
47.08
Interspecies Antigen Sequence
Mouse (90); Rat (92)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — ITPA
Entrez GeneID
3704GeneBank Accession#
BC010138Protein Accession#
AAH10138Gene Name
ITPA
Gene Alias
C20orf37, HLC14-06-P, ITPase, dJ794I6.3
Gene Description
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
Omim ID
147520Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. The encoded protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency. Two transcript variants encoding two different isoforms have been found for this gene. Also, at least two other transcript variants have been identified which are probably regulatory rather than protein-coding. [provided by RefSeq
Other Designations
My049 protein|OTTHUMP00000030094|inosine triphosphatase|inosine triphosphatase-A|inosine triphosphate pyrophosphatase|inosine triphosphate pyrophosphohydrolase|nucleoside triphosphate diphosphatase|putative oncogene protein HLC14-06-P
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Interactome
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Pathway
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Disease
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Publication Reference
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Erythrocyte Inosine Triphosphatase Activity Is Decreased in HIV-Seropositive Individuals.
Bierau J, Bakker JA, Schippers JA, Grashorn JA, Lindhout M, Lowe SH, Paulussen AD, Verbon A.
PLoS One 2012 Jan; 7(1):e30175.
Application：Enzyme, Human, Erythrocytes from HIV+ patients.
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Erythrocyte Inosine Triphosphatase Activity Is Decreased in HIV-Seropositive Individuals.
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