Products

Western Blot (Transfected lysate)

Immunofluorescence (Transfected cell)

Flow Cytometry (Transfected cell)

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

EIF6

Gene Alias

2, CAB, EIF3A, ITGB4BP, b, b(2)gcn, gcn, p27BBP

Gene Description

eukaryotic translation initiation factor 6

Omim ID

Gene Ontology

Gene Summary

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq

Other Designations

B4 integrin interactor|OTTHUMP00000030734|OTTHUMP00000061360|OTTHUMP00000061361|eukaryotic translation initiation factor 3A|integrin beta 4 binding protein|p27 beta-4 integrin-binding protein