IL12B monoclonal antibody (M01), clone 2H6
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant IL12B.
Immunogen
IL12B (NP_002178, 229 a.a. ~ 328 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
IRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Rat (66%)
Isotype
IgG2a Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
IL12B monoclonal antibody (M01), clone 2H6. Western Blot analysis of IL12B expression in HepG2.Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged IL12B is 0.3 ng/ml as a capture antibody.ELISA
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Gene Info — IL12B
Entrez GeneID
3593GeneBank Accession#
NM_002187Protein Accession#
NP_002178Gene Name
IL12B
Gene Alias
CLMF, CLMF2, IL-12B, NKSF, NKSF2
Gene Description
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Gene Ontology
HyperlinkGene Summary
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq
Other Designations
IL12, subunit p40|OTTHUMP00000160820|cytotoxic lymphocyte maturation factor 2, p40|interleukin 12, p40|interleukin 12B|interleukin-12 beta chain|natural killer cell stimulatory factor, 40 kD subunit|natural killer cell stimulatory factor-2
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Interactome
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Disease
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