IRF8 polyclonal antibody (A01)
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More Files
- More Functions
Western Blot detection against Immunogen (36.78 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant IRF8.
Immunogen
IRF8 (NP_002154, 122 a.a. ~ 218 a.a) partial recombinant protein with GST tag.
Sequence
LGVATAGCVNEVTEMECGRSEIDELIKEPSVDDYMGMIKRSPSPPEACRSQLLPDWWAQQPSTGVPLVTGYTTYDAHHSAFSQMVISFYYGGKLVGQ
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (86); Rat (85)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.78 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — IRF8
Entrez GeneID
3394GeneBank Accession#
NM_002163Protein Accession#
NP_002154Gene Name
IRF8
Gene Alias
H-ICSBP, ICSBP, ICSBP1, IRF-8
Gene Description
interferon regulatory factor 8
Omim ID
601565Gene Ontology
HyperlinkGene Summary
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq
Other Designations
interferon consensus sequence binding protein 1
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Interactome
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Disease
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Publication Reference
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IFN-gamma activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production.
Conzelmann M, Wagner AH, Hildebrandt A, Rodionova E, Hess M, Zota A, Giese T, Falk CS, Ho AD, Dreger P, Hecker M, Luft T.
Biochemical Pharmacology 2010 Dec; 80(12):2074.
Application：WB-Tr, Human, Human monocyte-derived dendritic cells.
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IFN-gamma activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production.
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