HNRPF (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human HNRPF full-length ORF ( NP_004957.1, 1 a.a. - 415 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MMLGPEGGEGFVVKLRGLPWSCSVEDVQNFLSDCTIHDGAAGVHFIYTREGRQSGEAFVELGSEDDVKMALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLERMRPGAYSTGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGLESQSVSGCYGAGYSGQNSMGGYD
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
72.1
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — HNRNPF
Entrez GeneID
3185GeneBank Accession#
NM_004966.2Protein Accession#
NP_004957.1Gene Name
HNRNPF
Gene Alias
HNRPF, MGC110997, OK/SW-cl.23, mcs94-1
Gene Description
heterogeneous nuclear ribonucleoprotein F
Omim ID
601037Gene Ontology
HyperlinkGene Summary
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs which have guanosine-rich sequences. This protein is very similar to the family member hnRPH. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
HnRNP F protein|OTTHUMP00000019482|OTTHUMP00000043413|OTTHUMP00000043414|nucleolin-like protein
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Interactome
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Disease
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Publication Reference
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Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.
Romano S, Moura V, Simões S, Moreira JN, Gonçalves J.
Scientific Reports 2018 May; 8(1):7450.
Application:ELISA, Flow Cyt, Human, MDA-MB-435S, 4T1 cells.
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Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.
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