HLA-DQB1 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-HLA-DQB1 full-length
Host
Human
Theoretical MW (kDa)
29.9
Interspecies Antigen Sequence
Mouse (75); Rat (75)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-HLA-DQB1 antibody (H00003119-B01) by Western Blots.
SDS-PAGE Gel
HLA-DQB1 transfected lysate
Western Blot
Lane 1: HLA-DQB1 transfected lysate ( 29.9 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — HLA-DQB1
Entrez GeneID
3119GeneBank Accession#
BC012106Protein Accession#
AAH12106Gene Name
HLA-DQB1
Gene Alias
CELIAC1, HLA-DQB, IDDM1
Gene Description
major histocompatibility complex, class II, DQ beta 1
Gene Ontology
HyperlinkGene Summary
HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq
Other Designations
MHC DQ beta|MHC class II DQ beta chain|MHC class II HLA-DQ beta glycoprotein|MHC class II antigen DQB1|MHC class II antigen HLA-DQ-beta-1|MHC class2 antigen|OTTHUMP00000178570|lymphocyte antigen|major histocompatibility complex class II beta
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Interactome
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Disease
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